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Synthesis and anti-HCV activity of 2′-β-hydroxymethylated nucleosides

Title
Synthesis and anti-HCV activity of 2′-β-hydroxymethylated nucleosides
Authors
Jeong L.S.Yoo B.N.Kim H.O.Lee K.M.Moon H.R.
Ewha Authors
이강만정낙신
SCOPUS Author ID
이강만scopus
Issue Date
2007
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 26, no. 41432, pp. 725 - 728
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Synthesis of 2′-β-hydroxymethyl nucleosides 3-6 was accomplished, using stereoselective hydroxymethylation as a key step. Adenine nucleoside 3 showed potent anti-HCV activity, implying that 2′-β- hydroxymethyl group has the appropriate electronic properties interfering with HCV polymerase. Copyright © Taylor & Francis Group, LLC.
DOI
10.1080/15257770701493310
Appears in Collections:
약학대학 > 약학과 > Journal papers
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