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A review: the trend of progress about pH probes in cell application in recent years

Title
A review: the trend of progress about pH probes in cell application in recent years
Authors
Yue, YongkangHuo, FangjunLee, SongyiYin, CaixiaYoon, Juyoung
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2017
Journal Title
ANALYST
ISSN
0003-2654JCR Link1364-5528JCR Link
Citation
vol. 142, no. 1, pp. 30 - 41
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Intracellular pH values are some of the most important factors that govern biological processes and the acid-base homeostasis in cells, body fluids and organs sustains the normal operations of the body. Subcellular organelles including the acidic lysosomes and the alkalescent mitochondria undergo various processes such as intracellular digestion, ATP production and apoptosis. Due to their precise imaging capabilities, fluorescent probes have attracted great attention for the illustration of pH modulated processes. Furthermore, based on the unique acidic extracellular environment of acidic lysosomes, fluorescent probes can specifically be activated in cancer cells or tumors. In this review, recently reported lysosome and mitochondria specific pH imaging probes as well as pH-activatable cancer cell-targetable probes have been discussed.
DOI
10.1039/c6an01942k
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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