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Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer

Title
Development and Validation of a Six-Gene Recurrence Risk Score Assay for Gastric Cancer
Authors
Lee, Keun-WookLee, Sung SookHwang, Jun-EulJang, Hee-JinLee, Hyun-SungOh, Sang CheulLee, Sang HoSohn, Bo HwaKim, Sang BaeShim, Jae-JunJeong, WoojinCha, MinseCheong, Jae-HoCho, Jae YongLim, Jae YunPark, Eun SungKim, Sang CheolKang, Yoon-KooNoh, Sung HoonAjani, Jaffer A.Lee, Ju-Seog
Ewha Authors
정우진
SCOPUS Author ID
정우진scopus
Issue Date
2016
Journal Title
CLINICAL CANCER RESEARCH
ISSN
1078-0432JCR Link1557-3265JCR Link
Citation
vol. 22, no. 24, pp. 6228 - 6235
Publisher
AMER ASSOC CANCER RESEARCH
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Purpose: This study was aimed at developing and validating a quantitative multigene assay for predicting tumor recurrence after gastric cancer surgery. Experimental Design: Gene expression data were generated from tumor tissues of patients who underwent surgery for gastric cancer (n = 267, training cohort). Genes whose expression was significantly associated with activation of YAP1 (a frequently activated oncogene in gastrointestinal cancer), 5-year recurrence-free survival, and 5-year overall survival were first identified as candidates for prognostic genes (156 genes, P < 0.001). We developed the recurrence risk score (RRS) by using quantitative RT-PCR to identify genes whose expression levels were significantly associated with YAP1 activation and patient survival in the training cohort. Results: We based the RRS assay on 6 genes, IGFBP4, SFRP4, SPOCK1, SULF1, THBS, and GADD45B, whose expression levels were significantly associated with YAP1 activation and prognosis in the training cohort. The RRS assay was further validated in an independent cohort of 317 patients. In multivariate analysis, the RRS was an independent predictor of recurrence [HR, 1.6; 95% confidence interval (CI), 1.02-2.4; P = 0.03]. In patients with stage II disease, the RRS had an HR of 2.9 (95% CI, 1.1-7.9; P = 0.03) and was the only significant independent predictor of recurrence. Conclusions: The RRS assay was a valid predictor of recurrence in the two cohorts of patients with gastric cancer. Independent prospective studies to assess the clinical utility of this assay are warranted. (C)2016 AACR.
DOI
10.1158/1078-0432.CCR-15-2468
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자연과학대학 > 생명과학전공 > Journal papers
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