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Synthesis and antitumor activity of DNA binding cationic porphyrin-platinum(II) complexes

Title
Synthesis and antitumor activity of DNA binding cationic porphyrin-platinum(II) complexes
Authors
Song R.Kim Y.-S.Lee C.O.Sohn Y.S.
Ewha Authors
손연수
SCOPUS Author ID
손연수scopus
Issue Date
2003
Journal Title
Tetrahedron Letters
ISSN
0040-4039JCR Link
Citation
vol. 44, no. 8, pp. 1537 - 1540
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to cisplatin (T/C%, 184) against the leukemia L1210 cell line. © 2003 Published by Elsevier Science Ltd.
DOI
10.1016/S0040-4039(03)00022-4
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자연과학대학 > 화학·나노과학전공 > Journal papers
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