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Rational design of biologically important chemosensors: A novel receptor for selective recognition of acetylcholine over ammonium cations

Title
Rational design of biologically important chemosensors: A novel receptor for selective recognition of acetylcholine over ammonium cations
Authors
Yun S.Kim Y.-O.Kim D.Kim H.G.Ihm H.Kim J.K.Lee C.-W.Lee W.J.Yoon J.Oh K.S.Park S.-M.Kim K.S.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2003
Journal Title
Organic Letters
ISSN
1523-7060JCR Link
Citation
vol. 5, no. 4, pp. 471 - 474
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
(Matrix presented) In consideration of competition between cation-π and hydrogen bond interaction forces, we designed a novel receptor, 1,3,5-tris(pyrrolyl)benzene, which shows high selectivity for acetylcholine (ACh). The selectivity of the receptor for ACh over other ammonium cations is demonstrated by the ion-selective electrode (ISE) method in buffer solution. The binding free energy of the receptor with ACh in chloroform solution is measured to be 3.65 kcal/mol in the presence of chloride anion by nuclear magnetic resonance spectroscopy, and that in water is estimated to be much greater (∼6 kcal/mol).
DOI
10.1021/ol0273203
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자연과학대학 > 화학·나노과학전공 > Journal papers
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