View : 19 Download: 0

Synthesis of novel taxoid analogue containing sulfur group on C-13 side-chain: 2′-deoxy-2′-epi-mercaptopaclitaxel

Title
Synthesis of novel taxoid analogue containing sulfur group on C-13 side-chain: 2′-deoxy-2′-epi-mercaptopaclitaxel
Authors
Qi X.Lee S.-H.Yoon J.Lee Y.-S.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2003
Journal Title
Tetrahedron
ISSN
0040-4020JCR Link
Citation
vol. 59, no. 37, pp. 7409 - 7412
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Paclitaxel analogues with a thiol group in place of the hydroxyl group on the C-13 side-chain constitute an interesting avenue of research for the study of new taxoid compounds. A synthetic route for the preparation of 2′-deoxy-2′-epi-mercaptopaclitaxel with high ee has been developed. The key step is the regio-controlled ring-opening reaction of the trans-oxazoline derivative with thiolacetic acid, which allows the introduction of the sulfur-containing group onto the side-chain. © 2003 Elsevier Ltd. All rights reserved.
DOI
10.1016/S0040-4020(03)01098-6
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE