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Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase

Title
Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-Adenosylhomocysteine hydrolase
Authors
Jeong L.S.Moon H.R.Park J.G.Shin D.H.Choi W.J.Lee K.M.Kim H.O.Chun M.W.Kim H.-D.Kim J.H.
Ewha Authors
정낙신
Issue Date
2003
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 22, no. 5-8, pp. 589 - 592
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
DOI
10.1081/NCN-120021961
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약학대학 > 약학과 > Journal papers
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