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Synthesis and biological evaluation of pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring

Title
Synthesis and biological evaluation of pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring
Authors
Chun M.W.Kim M.J.Kim H.O.Moon H.R.Kim H.-D.Kim J.H.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2003
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 22, no. 5-8, pp. 719 - 721
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Pyrimidine nucleosides fused with 3′,4′-tetrahydrofuran ring were synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities. Thymine analogue 1 and its corresponding 2′-deoxy analogue 3 exhibited high cytotoxicity instead of giving antiviral activities.
DOI
10.1081/NCN-120022618
Appears in Collections:
약학대학 > 약학과 > Journal papers
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