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Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A

Title
Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A
Authors
Moon H.R.Kwon S.H.Lee J.A.Yoo B.N.Kim H.O.Chun M.W.Kim H.-D.Kim J.H.Jeong L.S.
Ewha Authors
정낙신
Issue Date
2003
Journal Title
Nucleosides, Nucleotides and Nucleic Acids
ISSN
1525-7770JCR Link
Citation
vol. 22, no. 5-8, pp. 1475 - 1477
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed.
DOI
10.1081/NCN-120023014
Appears in Collections:
약학대학 > 약학과 > Journal papers
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