Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김대기 | * |
dc.date.accessioned | 2017-01-05T02:01:13Z | - |
dc.date.available | 2017-01-05T02:01:13Z | - |
dc.date.issued | 2003 | * |
dc.identifier.issn | 0022-2623 | * |
dc.identifier.other | OAK-1758 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233674 | - |
dc.description.abstract | Inhibitors of histone deacetylases (HDACs) have been shown to induce differentiation and/or apoptosis of human tumor cells. Novel 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides have been prepared as a new class of HDAC inhibitors and evaluated for their antiproliferative activity and HDAC inhibitory activity. Incorporation of a 1,4-phenylene carboxamide linker, shown by 5, and a 4-(dimethylamino)phenyl or 4-(pyrrolidin-1-yl)phenyl group as a cap substructure generated highly potent hydroxamic acid-based HDAC inhibitors 5a and 5b. | * |
dc.language | English | * |
dc.title | Synthesis and Biological Evaluation of 3-(4-Substituted-phenyl)-N-hydroxy-2-propenamides, a New Class of Histone Deacetylase Inhibitors | * |
dc.type | Article | * |
dc.relation.issue | 26 | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 5745 | * |
dc.relation.lastpage | 5751 | * |
dc.relation.journaltitle | Journal of Medicinal Chemistry | * |
dc.identifier.doi | 10.1021/jm030377q | * |
dc.identifier.wosid | WOS:000187243700020 | * |
dc.identifier.scopusid | 2-s2.0-10744229506 | * |
dc.author.google | Kim D.-K. | * |
dc.author.google | Lee J.Y. | * |
dc.author.google | Kim J.-S. | * |
dc.author.google | Ryu J.-H. | * |
dc.author.google | Choi J.-Y. | * |
dc.author.google | Lee J.W. | * |
dc.author.google | Im G.-J. | * |
dc.author.google | Kim T.-K. | * |
dc.author.google | Seo J.W. | * |
dc.author.google | Park H.-J. | * |
dc.author.google | Yoo J. | * |
dc.author.google | Park J.-H. | * |
dc.author.google | Kim T.-Y. | * |
dc.author.google | Bang Y.-J. | * |
dc.contributor.scopusid | 김대기(35083694200) | * |
dc.date.modifydate | 20240118164500 | * |