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Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats

Title
Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats
Authors
Kang E.S.Lee G.T.Kim B.S.Kim C.H.Seo G.H.Han S.J.Hur K.Y.Ahn C.W.Ha H.Jung M.Ahn Y.S.Cha B.S.Lee H.C.
Ewha Authors
하헌주
SCOPUS Author ID
하헌주scopus
Issue Date
2008
Journal Title
European Journal of Pharmacology
ISSN
0014-2999JCR Link
Citation
vol. 579, no. 41277, pp. 418 - 425
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal models. In the present study we investigated the effects of LAB on the prevention of diabetic nephropathy in type 2 diabetic Otsuka Long-Evans-Tokushima Fatty (OLETF) rats. LAB (20 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. Treatment of OLETF rats with LAB had little effects on body weight and blood glucose levels. Treatment with LAB resulted in significant reduction in blood pressure. LAB markedly attenuated albuminuria and significantly lowered levels of lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-β (TGF-β1) expression in renal tissues of OLETF rats. In addition, LAB inhibited the progression of glomerular hypertrophy, mesangial expansion, and expansion of the extracellular matrix in the renal cortex. Collectively, these results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing blood pressure, oxidative stress, and MCP-1 expression. Our results suggest that LAB might be a new therapeutic agent for the prevention of nephropathy in type 2 diabetes. © 2007 Elsevier B.V. All rights reserved.
DOI
10.1016/j.ejphar.2007.10.070
Appears in Collections:
약학대학 > 약학과 > Journal papers
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