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Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells

Title
Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells
Authors
Min H.-Y.Park E.-J.Hong J.-Y.Kang Y.-J.Kim S.-J.Chung H.-J.Woo E.-R.Hung T.M.Youn U.J.Kim Y.S.Kang S.S.Bae K.Lee S.K.
Ewha Authors
이상국
Issue Date
2008
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 18, no. 2, pp. 523 - 526
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3′, and C-4′, the hydroxyl group at C-8′, and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2007.11.082
Appears in Collections:
약학대학 > 약학과 > Journal papers
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