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Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body

Title
Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body
Authors
Eun B.Lee Y.Hong S.Kim J.Lee H.-W.Kim K.Sun W.Kim H.
Ewha Authors
김재상
SCOPUS Author ID
김재상scopus
Issue Date
2008
Journal Title
Journal of Biological Chemistry
ISSN
0021-9258JCR Link
Citation
vol. 283, no. 9, pp. 5939 - 5949
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Hes6 is a basic helix-loop-helix transcription factor that functions in the differentiation of pluripotent progenitor cells and during tumorigenesis. However, the molecular mechanism for its function is largely unknown. Here we show that Hes6 is a component of the promyelocytic leukemia nuclear body (PML-NB) complex in the nuclei and that Hes6 inhibits cell proliferation through induction of p21 cyclin-dependent kinase inhibitor. We further show that Hes6 directly interacts with CREB-binding protein (CBP), one of the key components of PML-NB, via its basic domain. This association is critical for p21 induction through multiple mechanisms, including chromatin remodeling and p53 acetylation. Taken together, these results suggest that the Hes6-CBP complex in PML-NB may influence the proliferation of cells via p53-dependent and-independent pathways. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc.
DOI
10.1074/jbc.M707683200
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자연과학대학 > 생명과학전공 > Journal papers
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