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Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn2+ in aqueous solution

Title
Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn2+ in aqueous solution
Authors
Joshi B.P.Cho W.-M.Kim J.Yoon J.Lee K.-H.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2007
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 17, no. 23, pp. 6425 - 6429
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A new fluorescent peptide probe for the detection of Zn2+ was synthesized on the basis of zinc binding ligands in zinc enzymes. The peptide that has a unique amino acid sequence displayed a great selectivity for Zn2+ in the presence of several transition metal ions in aqueous solution. The reversibility, binding stoichiometry, binding affinity, and pH sensitivity of the sensor were studied. Further, on-bead application of the peptide as chemosensors was demonstrated. © 2007 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2007.10.008
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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