Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 여창열 | * |
dc.date.accessioned | 2017-01-05T02:01:01Z | - |
dc.date.available | 2017-01-05T02:01:01Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0006-291X | * |
dc.identifier.other | OAK-4670 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233565 | - |
dc.description.abstract | Sirt2 is a mammalian member of the Sirtuin family of NAD+ (nicotinamide adenine dinucleotide)-dependent protein deacetylases. Although Sir-2.1 (a Caenorhabditis elegans Sirt2 ortholog) has been reported to interact with PAR-5/FTT-2 (a C. elegans 14-3-3 homolog), the molecular significance of the interaction between Sirt2 and 14-3-3 proteins in mammalian cell is not understood. Here, we report that Sirt2 interacts with 14-3-3 β and γ among various 14-3-3 isoforms, and that this interaction is strengthened by AKT. Furthermore, Sirt2 deacetylates and down-regulates the transcriptional activity of p53, and 14-3-3 β/γ augment deacetylation and down-regulation of the p53 transcriptional activity by Sirt2 in an AKT-dependent manner. Treatment of cells with nicotinamide, an inhibitor of Sirtuins, relieves the inhibition of p53 by Sirt2 and 14-3-3 β/γ. Therefore, our results suggest that the interaction between Sirt2 and 14-3-3 β/γ is a novel mechanism for the negative regulation of p53 beside the well-characterized Mdm2-mediated repression. © 2008 Elsevier Inc. All rights reserved. | * |
dc.language | English | * |
dc.title | Sirt2 interacts with 14-3-3 β/γ and down-regulates the activity of p53 | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 368 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 690 | * |
dc.relation.lastpage | 695 | * |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | * |
dc.identifier.doi | 10.1016/j.bbrc.2008.01.114 | * |
dc.identifier.wosid | WOS:000253925900038 | * |
dc.identifier.scopusid | 2-s2.0-39749143163 | * |
dc.author.google | Jin Y.-H. | * |
dc.author.google | Kim Y.-J. | * |
dc.author.google | Kim D.-W. | * |
dc.author.google | Baek K.-H. | * |
dc.author.google | Kang B.Y. | * |
dc.author.google | Yeo C.-Y. | * |
dc.author.google | Lee K.-Y. | * |
dc.contributor.scopusid | 여창열(7102545519) | * |
dc.date.modifydate | 20240419142344 | * |