Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수영 | * |
dc.contributor.author | 김재상 | * |
dc.date.accessioned | 2017-01-05T02:01:00Z | - |
dc.date.available | 2017-01-05T02:01:00Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 1350-9047 | * |
dc.identifier.other | OAK-4678 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233560 | - |
dc.description.abstract | TNF receptor-associated factor 6 (TRAF6) plays a key role in the regulation of innate immune responses by mediating signals from both TNF receptors (TNFRs) and interleukin-1 receptors (IL-1Rs)/Toll-like receptors (TLRs). Here, we define a new role for TRAF6 in antagonizing cell death during TNF signaling. In TRAF6-deficient 3T3 (T6 -/- 3T3) cells, TNF stimulation leads to the accumulation of reactive oxygen species (ROS), which in turn results in prolonged c-Jun N-terminal kinase (JNK) activation and accelerated cell death. Furthermore, TNF-induced p65/RelA phosphorylation as well as transcriptional activity of nuclear factor-κB (NF-κB) was significantly downregulated in T6 -/- 3T3 cells. Interestingly, TRAF6 deficiency leads to constitutive phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β). Restoration of GSK3β activity through exogenous expression of a GSK3β constitutive active form rescued cell death in TRAF6-null 3T3 cells. These data suggest a role for TRAF6 in the maintenance of cell survival by regulating GSK3β activity in TNF signaling. | * |
dc.language | English | * |
dc.title | TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3β | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 15 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 730 | * |
dc.relation.lastpage | 738 | * |
dc.relation.journaltitle | Cell Death and Differentiation | * |
dc.identifier.doi | 10.1038/sj.cdd.4402304 | * |
dc.identifier.wosid | WOS:000254041800016 | * |
dc.identifier.scopusid | 2-s2.0-40949110878 | * |
dc.author.google | Yoon K. | * |
dc.author.google | Jung E.J. | * |
dc.author.google | Lee S.R. | * |
dc.author.google | Kim J. | * |
dc.author.google | Choi Y. | * |
dc.author.google | Lee S.Y. | * |
dc.contributor.scopusid | 이수영(53980218900;7409697278) | * |
dc.contributor.scopusid | 김재상(8643335800) | * |
dc.date.modifydate | 20240415140424 | * |