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TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3β cascade is required for TNF-induced cell survival

Title
TRAF6-mediated regulation of the PI3 kinase (PI3K)-Akt-GSK3β cascade is required for TNF-induced cell survival
Authors
Yoon K.Jung E.J.Lee S.Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopus
Issue Date
2008
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
vol. 371, no. 1, pp. 118 - 121
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We recently demonstrated that the tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) helps maintenance of cell survival by regulating glycogen synthase kinase 3β (GSK3β) activity during TNF signaling. However, the molecular linkage between TRAF6 and GSK3β signaling is unknown. Herein, we showed that TRAF6 positively regulated cell survival by modulating PI3K-Akt-GSK3β cascades. In 3T3 cells lacking TRAF6, but not those lacking TRAF2, TNF stimulation led to prolonged hyperphosphorylation of Akt, which coincided with the activation of upstream PI3K. Pharmacologically blocking PI3K significantly inhibited Akt and GSK3β phosphorylation. Importantly, PI3K inhibition rescued cell death in TRAF6-null 3T3 cells. These data suggested TRAF6 regulates TNF-mediated cell survival through PI3K-Akt-GSK3β cascades. © 2008 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2008.04.007
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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