Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 박혜영 | - |
dc.date.accessioned | 2017-01-05T02:01:53Z | - |
dc.date.available | 2017-01-05T02:01:53Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.other | OAK-4823 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233495 | - |
dc.description.abstract | Twenty-four compounds of 4-methoxy-N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] benzene sulfonamides and N-[3-(4-substituted phenyl-piperazine-1-yl)propyl] naphthyl sulfonamides were prepared and evaluated as 5-HT7 receptor antagonists. Most of the compounds showed the IC50 values of 12-580 nM. Four methyl branched analogues were also obtained, but the activity for methyl branched analogues was almost same as its straight chain congeners. Among the synthesized compounds, 3c showed a good activity on 5-HT7 receptors and a good selectivity on 5-HT1a, 5-HT2a, 5-HT2c, and 5-HT6 receptors. © 2008 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Preparation of piperazine derivatives as 5-HT7 receptor antagonists | - |
dc.type | Article | - |
dc.relation.issue | 10 | - |
dc.relation.volume | 16 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 5405 | - |
dc.relation.lastpage | 5412 | - |
dc.relation.journaltitle | Bioorganic and Medicinal Chemistry | - |
dc.identifier.doi | 10.1016/j.bmc.2008.04.023 | - |
dc.identifier.wosid | WOS:000256052400005 | - |
dc.identifier.scopusid | 2-s2.0-43749091957 | - |
dc.author.google | Yoon J. | - |
dc.author.google | Yoo E.A. | - |
dc.author.google | Kim J.-Y. | - |
dc.author.google | Pae A.N. | - |
dc.author.google | Rhim H. | - |
dc.author.google | Park W.-K. | - |
dc.author.google | Kong J.Y. | - |
dc.author.google | Park Choo H.-Y. | - |
dc.contributor.scopusid | 박혜영(34972649500;57200273796) | - |
dc.date.modifydate | 20230411110509 | - |