Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤여준 | - |
dc.date.accessioned | 2017-01-05T02:01:52Z | - |
dc.date.available | 2017-01-05T02:01:52Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0168-1656 | - |
dc.identifier.other | OAK-4851 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233481 | - |
dc.description.abstract | Ketolides, characterized by possessing a 3-keto group in place of the l-cladinose moiety of erythromycin A, are the recent generation of antimicrobials derived semi-synthetically from the 14-membered ring macrolide erythromycin A. The multi-step synthetic route to ketolides can be shortened by using 5-O-desosaminyl erythronolide A as a precursor, which reduces the steps for the removal of l-cladinose attached at the C-3 position in erythromycin A. Deletion of an eryBV gene encoding mycarosyl glycosyltransferase in the erythromycin-producer Saccharopolyspora erythraea resulted in the accumulation of 5-O-desosaminyl erythronolide B. In vivo expression of the cytochrome P450 gene pikC, which encodes the substrate-flexible hydroxylase from the pikromycin biosynthetic pathway of Streptomyces venezuelae, in the eryBV deletion mutant strain of Sac. erythraea led to 5-O-desosaminyl erythronolide A production. © 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.title | Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 135 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 92 | - |
dc.relation.lastpage | 96 | - |
dc.relation.journaltitle | Journal of Biotechnology | - |
dc.identifier.doi | 10.1016/j.jbiotec.2008.03.001 | - |
dc.identifier.wosid | WOS:000256511300013 | - |
dc.identifier.scopusid | 2-s2.0-43049128476 | - |
dc.author.google | Basnet D.B. | - |
dc.author.google | Park J.W. | - |
dc.author.google | Yoon Y.J. | - |
dc.contributor.scopusid | 윤여준(7402126465) | - |
dc.date.modifydate | 20210708161345 | - |