View : 13 Download: 0

Metabolites of amygdalin under simulated human digestive fluids

Title
Metabolites of amygdalin under simulated human digestive fluids
Authors
Shim S.-M.Kwon H.
Ewha Authors
심순미
Issue Date
2010
Journal Title
International Journal of Food Sciences and Nutrition
ISSN
0963-7486JCR Link
Citation
vol. 61, no. 8, pp. 770 - 779
Indexed
SCIE; SCOPUS WOS scopus
Abstract
In the present study, degradation of amygdalin in the human digestive fluids and absorption of its metabolites by the human small intestine were evaluated by simulating a gastrointestinal digestion model combined with a human intestinal cell culture. Orally administered amygdalin was degraded into prunasin by digestive enzymes after passing through the salivary and gastrointestinal phases. Prunasin, the major metabolite of amygdalin in the digestive fluids, was incubated in a caco-2 cell culture system. Prunasin was degraded into the mandelonitrile by β-glucosidase and then hydroxylated across the small intestinal wall, producing hydroxymandelonitrile (149 Da). Results from this study suggest that risk assessment of amygdalin from food consumption can be done in a more accurate way by determining a pathway of amygdalin metabolism in the simulating human upper gastrointestinal tract. © 2010 Informa UK, Ltd.
DOI
10.3109/09637481003796314
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE