View : 43 Download: 0

Single-dose oral acute toxicity and mutagenic effects of methanol extracts of Cirsium japonicum

Title
Single-dose oral acute toxicity and mutagenic effects of methanol extracts of Cirsium japonicum
Authors
Shim S.-M.Bae E.Kim G.-H.
Ewha Authors
심순미
Issue Date
2011
Journal Title
Journal of Food Biochemistry
ISSN
0145-8884JCR Link
Citation
vol. 35, no. 3, pp. 845 - 858
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The purpose of this study was to evaluate safety on Cirsium japonicum extracts containing flavones by examining acute oral toxicity, bacterial reverse mutation and the chromosome aberration test. Mutagenicity of extracts were evaluated by a bacterial reverse mutation assay using Salmonella typhimurium TA98, TA100, TA102, TA1535, TA1537 and Escherichia coli (WP2uvrA) with and without metabolic activation. An in vitro chromosome aberration test in Chinese hamster lung cells was conducted at the concentrations of 0, 1,250, 2,500 and 5,000μg/mL. No significant adverse effects on body weight, mortality and gross findings were observed for 15 days after a single dose (2,000mg of extracts/kg body weight) of administration. In the bacterial reverse mutation assay, C. japonicum extracts ranging from 156 to 5,000μg/plate did not induce base-pair substitution or frame shift. Any significant increase in structural aberration as well as reduction of cell cycle progression was not observed in the chromosome. © 2010 Wiley Periodicals, Inc.
DOI
10.1111/j.1745-4514.2010.00421.x
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE