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Outcome Analysis of Chemoradiation in Unresectable Pancreatic Cancer Focusing on Treatment Sequencing Strategy

Title
Outcome Analysis of Chemoradiation in Unresectable Pancreatic Cancer Focusing on Treatment Sequencing Strategy
Authors
Koh, Hyeon KangChie, Eui KyuKim, KyuboJang, Jin-YoungKim, Sun WheOh, Do-YounIm, Seock-AhBang, Yung-JueHa, Sung W.
Ewha Authors
김규보
SCOPUS Author ID
김규보scopusscopus
Issue Date
2016
Journal Title
ANTICANCER RESEARCH
ISSN
0250-7005JCR Link1791-7530JCR Link
Citation
vol. 36, no. 10, pp. 5455 - 5461
Keywords
Pancreatic cancerchemoradiotherapychemotherapyradiation dose
Publisher
INT INST ANTICANCER RESEARCH
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Aim: To analyze the outcomes of patients with unresectable pancreatic cancer after chemoradiotherapy (CCRT), focusing on sequencing strategy. Patients and Methods: Data of 144 patients treated from January 1989 to December 2013 were retrospectively analyzed. Patients were divided into the scheduled group (N=27), salvage group (N=37) and upfront group (N=80) per CCRT and chemotherapy sequence. Results: With a median follow-up of 10.4 months (range=1.4-164.2), median overall survival (OS) was 13.5 months. Patients in the upfront group had inferior performance status and received a lower radiation dose (p=0.007 and p<0.001, respectively). Higher radiation dose (=45 Gy) was the sole prognosticator related with improved survival in multivariate (p=0.001) analysis, whereas treatment sequence was not a significant prognostic factor (p=0.409). Conclusion: No difference was found among tested sequencing strategies that were all well-tolerated, despite skewed distribution for performance and radiation dose. An upfront approach may be a viable option for patients with limited performance to undergo more active systemic chemotherapy.
DOI
10.21873/anticanres.11125
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의학전문대학원 > 의학과 > Journal papers
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