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Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression
- Title
- Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression
- Authors
- Cho, Kyung-Ah; Park, Minhwa; Kim, Yu-Hee; Ryu, Kyung-Ha; Woo, So-Youn
- Ewha Authors
- 유경하; 우소연; 김유희; 조경아
- SCOPUS Author ID
- 유경하; 우소연; 김유희; 조경아
- Issue Date
- 2017
- Journal Title
- IMMUNOBIOLOGY
- ISSN
- 0171-2985
- Citation
- IMMUNOBIOLOGY vol. 222, no. 2, pp. 394 - 398
- Keywords
- Tonsil-derived MSCs; PD-L1; Th17; Poly I:C
- Publisher
- ELSEVIER GMBH, URBAN &
FISCHER VERLAG
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- It has been established that mesenchymal stem cells (MSCs) can have a suppressive effect on T cells, yet much remains unknown about the underlying mechanisms that support this effect. The T cell co stimulatory pathway involving the programmed death-1 (PD-1) receptor and its ligand PD-L1 regulates T cell activation, tolerance, and subsequent immune-mediated tissue damage. In this study, human palatine tonsil-derived MSCs (T-MSCs) constitutively expressed PD-L1 and exhibited a suppressive activity that specifically targeted murine Th17 differentiation. Additionally, polyinosinic-polycytidylic acid (poly 1:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs. The elevated PD-L1 levels enhanced the suppressive functions of T-MSCs on Th17 differentiation. Therefore, pre-stimulation of T-MSCs with poly I:C may serve as an effective therapeutic priming step for modulating Th17-dominant immune responses. (C) 2016 Elsevier GmbH. All rights reserved.
- DOI
- 10.1016/j.imbio.2016.08.012
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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