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Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression

Title
Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression
Authors
Cho, Kyung-AhPark, MinhwaKim, Yu-HeeRyu, Kyung-HaWoo, So-Youn
Ewha Authors
유경하우소연김유희조경아
SCOPUS Author ID
유경하scopus; 우소연scopus; 김유희scopus; 조경아scopus
Issue Date
2017
Journal Title
IMMUNOBIOLOGY
ISSN
0171-2985JCR Link
Citation
vol. 222, no. 2, pp. 394 - 398
Keywords
Tonsil-derived MSCsPD-L1Th17Poly I:C
Publisher
ELSEVIER GMBH, URBAN & FISCHER VERLAG
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
It has been established that mesenchymal stem cells (MSCs) can have a suppressive effect on T cells, yet much remains unknown about the underlying mechanisms that support this effect. The T cell co stimulatory pathway involving the programmed death-1 (PD-1) receptor and its ligand PD-L1 regulates T cell activation, tolerance, and subsequent immune-mediated tissue damage. In this study, human palatine tonsil-derived MSCs (T-MSCs) constitutively expressed PD-L1 and exhibited a suppressive activity that specifically targeted murine Th17 differentiation. Additionally, polyinosinic-polycytidylic acid (poly 1:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs. The elevated PD-L1 levels enhanced the suppressive functions of T-MSCs on Th17 differentiation. Therefore, pre-stimulation of T-MSCs with poly I:C may serve as an effective therapeutic priming step for modulating Th17-dominant immune responses. (C) 2016 Elsevier GmbH. All rights reserved.
DOI
10.1016/j.imbio.2016.08.012
Appears in Collections:
의과대학 > 의학과 > Journal papers
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