Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유경하 | * |
dc.contributor.author | 우소연 | * |
dc.contributor.author | 김유희 | * |
dc.contributor.author | 조경아 | * |
dc.date.accessioned | 2016-12-28T02:12:38Z | - |
dc.date.available | 2016-12-28T02:12:38Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0171-2985 | * |
dc.identifier.other | OAK-19696 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233355 | - |
dc.description.abstract | It has been established that mesenchymal stem cells (MSCs) can have a suppressive effect on T cells, yet much remains unknown about the underlying mechanisms that support this effect. The T cell co stimulatory pathway involving the programmed death-1 (PD-1) receptor and its ligand PD-L1 regulates T cell activation, tolerance, and subsequent immune-mediated tissue damage. In this study, human palatine tonsil-derived MSCs (T-MSCs) constitutively expressed PD-L1 and exhibited a suppressive activity that specifically targeted murine Th17 differentiation. Additionally, polyinosinic-polycytidylic acid (poly 1:C), a Toll-like receptor 3 (TLR3) ligand, increased PD-L1 expression on T-MSCs. The elevated PD-L1 levels enhanced the suppressive functions of T-MSCs on Th17 differentiation. Therefore, pre-stimulation of T-MSCs with poly I:C may serve as an effective therapeutic priming step for modulating Th17-dominant immune responses. (C) 2016 Elsevier GmbH. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER GMBH, URBAN & | * |
dc.publisher | FISCHER VERLAG | * |
dc.subject | Tonsil-derived MSCs | * |
dc.subject | PD-L1 | * |
dc.subject | Th17 | * |
dc.subject | Poly I:C | * |
dc.title | Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 222 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 394 | * |
dc.relation.lastpage | 398 | * |
dc.relation.journaltitle | IMMUNOBIOLOGY | * |
dc.identifier.doi | 10.1016/j.imbio.2016.08.012 | * |
dc.identifier.wosid | WOS:000390735300032 | * |
dc.identifier.scopusid | 2-s2.0-84994071368 | * |
dc.author.google | Cho, Kyung-Ah | * |
dc.author.google | Park, Minhwa | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Ryu, Kyung-Ha | * |
dc.author.google | Woo, So-Youn | * |
dc.contributor.scopusid | 유경하(14038236200) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.date.modifydate | 20240222161025 | * |