Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 차선신 | * |
dc.date.accessioned | 2016-12-28T02:12:24Z | - |
dc.date.available | 2016-12-28T02:12:24Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0021-8561 | * |
dc.identifier.issn | 1520-5118 | * |
dc.identifier.other | OAK-19492 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233274 | - |
dc.description.abstract | Xanthomonas oryzae pv. oryzae (Xoo) causes bacterial blight on rice; this species is one of the most destructive pathogenic bacteria in rice cultivation worldwide. Peptide deformylase (PDF) catalyzes the removal of the N-formyl group from the N-terminus of newly synthesized polypeptides in bacterial cells and is an important target to develop antibacterial agents. We determined crystal structures of Xoo PDF (XoPDF) at up to 1.9 A resolution, which include apo, two substrate-bound (methionine-alanine or methionine-alanine-serine), an inhibitor-bound (actinonin), and six fragment chemical-bound structures. Six fragment chemical compounds were bound in the substrate-binding pocket. The fragment chemical-bound structures were compared to the natural PDF inhibitor actinonin-bound structure. The fragment chemical molecules will be useful to design an inhibitor specific to XoPDF and a potential pesticide against Xoo. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.subject | bacterial blight | * |
dc.subject | Xanthomonas oryzae pv. oryzae | * |
dc.subject | peptide deformylase | * |
dc.subject | pesticide | * |
dc.subject | fragment chemical | * |
dc.title | Crystal Structures of Peptide Deformylase from Rice Pathogen Xanthomonas oryzae pv. oryzae in Complex with Substrate Peptides, Actinonin, and Fragment Chemical Compounds | * |
dc.type | Article | * |
dc.relation.issue | 39 | * |
dc.relation.volume | 64 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 7307 | * |
dc.relation.lastpage | 7314 | * |
dc.relation.journaltitle | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | * |
dc.identifier.doi | 10.1021/acs.jafc.6b02976 | * |
dc.identifier.wosid | WOS:000384951500001 | * |
dc.identifier.scopusid | 2-s2.0-84990052469 | * |
dc.author.google | Ho-Phuong-Thuy Ngo | * |
dc.author.google | Thien-Hoang Ho | * |
dc.author.google | Lee, Inho | * |
dc.author.google | Huyen-Thi Tran | * |
dc.author.google | Sur, Bookyo | * |
dc.author.google | Kim, Seunghwan | * |
dc.author.google | Kim, Jeong-Gu | * |
dc.author.google | Ahn, Yeh-Jin | * |
dc.author.google | Cha, Sun-Shin | * |
dc.author.google | Kang, Lin-Woo | * |
dc.contributor.scopusid | 차선신(7201864593) | * |
dc.date.modifydate | 20240429134916 | * |