Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 황금숙 | * |
dc.date.accessioned | 2016-12-27T02:12:33Z | - |
dc.date.available | 2016-12-27T02:12:33Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0167-5273 | * |
dc.identifier.issn | 1874-1754 | * |
dc.identifier.other | OAK-19927 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233175 | - |
dc.description.abstract | Background: Myocardial infarction (MI) is caused by myocardial necrosis resulting from prolonged ischemia. However, the biological mechanisms underlying MI remain unclear. Methods: We evaluated metabolic and lipidomic changes in rat heart tissue from sham and MI at 1 h, 1 day and 10 day after coronary ligation, using global profiling based on metabolomics. Results: A time-dependent increase or decrease in polar and lipid metabolite levels was measured. The Sadenosylmethionine (SAM) concentration and the SAM/S-adenosylhomocysteine (SAH) ratio gradually decreased in a time-dependent manner and were significantly downregulated 10 days after MI. Transcriptome analysis revealed that the levels of coenzyme Q (Coq)-3 and Coq5, both of which are SAM-dependent methyl-transferases, were decreased in theMI groups. These results suggested that dysregulation of SAM may be related to down regulated COQ biosynthetic pathway. In addition, short-chain (C3) and medium-chain (C4-C12) acylcarnitine levels gradually decreased, whereas long-chain acylcarnitine (C14-18) levels increased, owing to a defect in beta-oxidation during ischemia. These changes are related to energy-dependent metabolic pathways, and a subsequent decrease in adenosine triphosphate concentration was observed. Conclusions: The comprehensive integration of various omics data provides a novel means of understanding the underlying pathophysiological mechanisms of MI. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER IRELAND LTD | * |
dc.subject | Integrative omics analysis | * |
dc.subject | Myocardial infarction | * |
dc.subject | Metabolomics | * |
dc.subject | Lipidomics | * |
dc.subject | Transcriptomics | * |
dc.title | A metabolomics-driven approach reveals metabolic responses and mechanisms in the rat heart following myocardial infarction | * |
dc.type | Article | * |
dc.relation.volume | 227 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 239 | * |
dc.relation.lastpage | 246 | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF CARDIOLOGY | * |
dc.identifier.doi | 10.1016/j.ijcard.2016.11.127 | * |
dc.identifier.wosid | WOS:000390480700042 | * |
dc.identifier.scopusid | 2-s2.0-85004075740 | * |
dc.author.google | Nam, Miso | * |
dc.author.google | Jung, Youngae | * |
dc.author.google | Ryu, Do Hyun | * |
dc.author.google | Hwang, Geum-Sook | * |
dc.contributor.scopusid | 황금숙(7202676099) | * |
dc.date.modifydate | 20240222154747 | * |