View : 42 Download: 0

Hydrophobic Guest Mediated Micellization and Demicellization of Rationally Designed Amphiphilic Poly(organophosphazene) for Efficient Drug Delivery

Title
Hydrophobic Guest Mediated Micellization and Demicellization of Rationally Designed Amphiphilic Poly(organophosphazene) for Efficient Drug Delivery
Authors
Kim, Myung HunJun, Yong JooElzatahry, AhmedAlothman, Zeid A.Vinu, AjayanBin Choy, YoungChoy, Jin-Ho
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2016
Journal Title
SCIENCE OF ADVANCED MATERIALS
ISSN
1947-2935JCR Link1947-2943JCR Link
Citation
vol. 8, no. 8, pp. 1553 - 1562
Keywords
Poly(organophosphazenes)ResveratrolMicellizationDemicellizationEfficient EncapsulationSustained DeliveryBiocompatibility
Publisher
AMER SCIENTIFIC PUBLISHERS
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Recently, biocompatible and amphiphilic poly(organophosphazene) (PPZ) has been suggested as a drug delivery carrier since it can be easily modified to achieve desired chemical properties. In this work, we newly designed a PPZ with balanced hydrophilicity and hydrophobicity by modulating the mole ratio of hydrophilic to hydrophobic substituents in the PPZ backbone to form hydrophobic drug, resveratrol (RSV), mediated micelle for efficient drug delivery. The feeding mass ratio of RSV and PPZ was optimized to be 1: 10 based on loading efficiency, loading capacity, and release kinetics and micelles were self-assembled due to hydrophobic intermolecular interaction above critical micelle concentration (20 mg/l). According to the in vitro study, RSV molecules encapsulated in the core of PPZ micelles were released out by demicellization in a sustained manner, resulting in reduction of perceived cytotoxicity of RSV. Therefore, the present PPZ is considered as an efficient drug delivery carrier for encapsulation and sustained delivery of hydrophobic drug molecules with acceptable biocompatibility.
DOI
10.1166/sam.2016.2762
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE