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dc.contributor.author정낙신-
dc.contributor.author이상국-
dc.date.accessioned2017-08-28T19:35:03Z-
dc.date.available2017-08-28T19:35:03Z-
dc.date.issued2008-
dc.identifier.issn0304-3835-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/233121-
dc.description.abstractHuman A3 adenosine receptor (A3AR) agonists showed the anti-tumor activity in various in vitro and in vivo studies. The present study investigates the anti-proliferative effect of a novel adenosine analog 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N-methyluronamide (thio-Cl-IB-MECA) in A549 human lung cancer cells. Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations (up to 20 μM) and apoptotic cell death at a higher concentration (80 μM), which were manifested by down-regulation of cyclin D1, c-myc, and CDK4, activation of caspase-3 and -9, and cleavage of poly(ADP-ribose) polymerase (PARP). The activation of Akt-mediated signaling was also inhibited by treatment with thio-Cl-IB-MECA. These data might suggest the potential therapeutic value of an adenosine analog in the treatment of human lung cancer. © 2008 Elsevier Ireland Ltd. All rights reserved.-
dc.languageEnglish-
dc.titleInhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume264-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage309-
dc.relation.lastpage315-
dc.relation.journaltitleCancer Letters-
dc.identifier.doi10.1016/j.canlet.2008.01.037-
dc.identifier.wosidWOS:000256776900017-
dc.identifier.scopusid2-s2.0-42749096768-
dc.author.googleKim S.-J.-
dc.author.googleMin H.-Y.-
dc.author.googleChung H.-J.-
dc.author.googlePark E.-J.-
dc.author.googleHong J.-Y.-
dc.author.googleKang Y.-J.-
dc.author.googleShin D.-H.-
dc.author.googleJeong L.S.-
dc.author.googleLee S.K.-
dc.date.modifydate20161212144035-
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약학대학 > 약학과 > Journal papers
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