Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 이상국 | - |
dc.date.accessioned | 2016-12-13T02:12:29Z | - |
dc.date.available | 2016-12-13T02:12:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | OAK-4878 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233121 | - |
dc.description.abstract | Human A3 adenosine receptor (A3AR) agonists showed the anti-tumor activity in various in vitro and in vivo studies. The present study investigates the anti-proliferative effect of a novel adenosine analog 2-chloro-N6-(3-iodobenzyl)-4′-thioadenosine-5′-N-methyluronamide (thio-Cl-IB-MECA) in A549 human lung cancer cells. Thio-Cl-IB-MECA induced arrest of cell cycle progression in G0/G1 phase at lower concentrations (up to 20 μM) and apoptotic cell death at a higher concentration (80 μM), which were manifested by down-regulation of cyclin D1, c-myc, and CDK4, activation of caspase-3 and -9, and cleavage of poly(ADP-ribose) polymerase (PARP). The activation of Akt-mediated signaling was also inhibited by treatment with thio-Cl-IB-MECA. These data might suggest the potential therapeutic value of an adenosine analog in the treatment of human lung cancer. © 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 264 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 309 | - |
dc.relation.lastpage | 315 | - |
dc.relation.journaltitle | Cancer Letters | - |
dc.identifier.doi | 10.1016/j.canlet.2008.01.037 | - |
dc.identifier.wosid | WOS:000256776900017 | - |
dc.identifier.scopusid | 2-s2.0-42749096768 | - |
dc.author.google | Kim S.-J. | - |
dc.author.google | Min H.-Y. | - |
dc.author.google | Chung H.-J. | - |
dc.author.google | Park E.-J. | - |
dc.author.google | Hong J.-Y. | - |
dc.author.google | Kang Y.-J. | - |
dc.author.google | Shin D.-H. | - |
dc.author.google | Jeong L.S. | - |
dc.author.google | Lee S.K. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 이상국(36067620500) | - |
dc.date.modifydate | 20211210153309 | - |