Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 최진호 | - |
dc.date.accessioned | 2016-12-13T02:12:29Z | - |
dc.date.available | 2016-12-13T02:12:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0022-3697 | - |
dc.identifier.other | OAK-4886 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/233117 | - |
dc.description.abstract | Methotrexate-layered double hydroxide (MTX-LDH) nanohybrid showed considerably enhanced cellular uptake and drug efficacy compared to free MTX. To evaluate the potential of drug-LDH nanohybrids as cancer chemotherapy agents, the present study was extended to encapsulate another anticancer drug, 5-fluorouracil (5-Fu) into LDH through coprecipitation method. The powder X-ray pattern of 5-Fu-LDH nanohybrid showed interlayer distance of 5.8 Å, which well corresponds to the longitudinal length of the drug molecule, indicating the successful intercalation. Drug efficacy of 5-Fu-LDH thus prepared was evaluated in several cancer cell lines such as human lung cancer, osteosarcoma, and hepatoma cells. Free 5-Fu, MTX, MTX-LDH, and doxorubicin (Dox) were also used for comparative studies. Our results demonstrated that both 5-Fu-LDH and MTX-LDH nanohybrids more effectively inhibited cancer cell proliferation than free 5-Fu and MTX, respectively, leading to cell death in a concentration-dependent manner. Among them, the highest drug efficacy was achieved by MTX-LDH nanohybrid, even higher than Dox, one of the most effective chemotherapy agents against a variety of cancers. Moreover, LDH itself did not exhibit acute cytotoxic effect up to 500 μg/ml as measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Therefore, this study suggests the great potential of anticancer drug-LDH nanohybrids as cancer chemotherapy agents. © 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.title | Anticancer drug-layered hydroxide nanohybrids as potent cancer chemotherapy agents | - |
dc.type | Article | - |
dc.relation.issue | 41400 | - |
dc.relation.volume | 69 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1528 | - |
dc.relation.lastpage | 1532 | - |
dc.relation.journaltitle | Journal of Physics and Chemistry of Solids | - |
dc.identifier.doi | 10.1016/j.jpcs.2007.10.140 | - |
dc.identifier.wosid | WOS:000256817000123 | - |
dc.identifier.scopusid | 2-s2.0-43449117484 | - |
dc.author.google | Choi S.-J. | - |
dc.author.google | Oh J.-M. | - |
dc.author.google | Choy J.-H. | - |
dc.contributor.scopusid | 최진호(8044393000) | - |
dc.date.modifydate | 20190301081000 | - |