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Regulation of Activin/Nodal Signaling by Rap2-Directed Receptor Trafficking

Title
Regulation of Activin/Nodal Signaling by Rap2-Directed Receptor Trafficking
Authors
Choi S.-C.Kim G.-H.Lee S.J.Park E.Yeo C.-Y.Han J.-K.
Ewha Authors
여창열
SCOPUS Author ID
여창열scopus
Issue Date
2008
Journal Title
Developmental Cell
ISSN
1534-5807JCR Link
Citation
vol. 15, no. 1, pp. 49 - 61
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We show that Rap2, a member of the Ras GTPase family, positively regulates Activin/Nodal signaling activity by controlling the trafficking of its receptors. In the absence of ligand activation, Rap2 directs internalized Activin/Nodal receptors into a recycling pathway, thereby preventing their degradation and maintaining their levels on the cell surface. Upon ligand activation, Rap2 no longer promotes receptor recycling but delays its turnover. In both cases, Rap2 contributes to upregulation of signaling activity by antagonizing Smad7. In addition, we found that the efficiency of Activin/Nodal receptor recycling is different between dorsal and ventral halves of Xenopus early embryo, which results from the asymmetric expression of Rap2 and Smad7. Consequently, they regulate cell responsiveness to ligands and the spatiotemporally dynamic activation of Smad2 along the dorsoventral axis of the embryo. Therefore, these findings suggest a molecular basis for the regulation of signaling activity and embryonic patterning by Activin/Nodal receptor trafficking. © 2008 Elsevier Inc. All rights reserved.
DOI
10.1016/j.devcel.2008.05.004
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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