DSpace at EWHA: Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

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DC Field	Value	Language
dc.contributor.author	김대기	*
dc.date.accessioned	2016-12-13T02:12:23Z	-
dc.date.available	2016-12-13T02:12:23Z	-
dc.date.issued	2008	*
dc.identifier.issn	0960-894X	*
dc.identifier.other	OAK-4950	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/233085	-
dc.description.abstract	A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively. © 2008 Elsevier Ltd. All rights reserved.	*
dc.language	English	*
dc.title	Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase	*
dc.type	Article	*
dc.relation.issue	14	*
dc.relation.volume	18	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	4006	*
dc.relation.lastpage	4010	*
dc.relation.journaltitle	Bioorganic and Medicinal Chemistry Letters	*
dc.identifier.doi	10.1016/j.bmcl.2008.06.007	*
dc.identifier.wosid	WOS:000257640400040	*
dc.identifier.scopusid	2-s2.0-47149103821	*
dc.author.google	Kim D.-K.	*
dc.author.google	Lim J.-H.	*
dc.author.google	Lee J.A.	*
dc.author.google	Dewang P.M.	*
dc.contributor.scopusid	김대기(35083694200)	*
dc.date.modifydate	20240118164500	*