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Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells

Title
Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells
Authors
Jeong, Eun HyeRyu, Ji HyunJeong, HansaemJang, BoraLee, Ho YeonHong, SeonkiLee, HaeshinLee, Hyukjin
Ewha Authors
이혁진
SCOPUS Author ID
이혁진scopus
Issue Date
2014
Journal Title
CHEMICAL COMMUNICATIONS
ISSN
1359-7345JCR Link1364-548XJCR Link
Citation
vol. 50, no. 87, pp. 13388 - 13390
Publisher
ROYAL SOC CHEMISTRY
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Polymer gold nanoshells (PGNs) are prepared by a novel plant-inspired flavonoid surface modification method. The PGNs show dramatic photothermal properties, which can facilitate the endosomal escape and delivery of siRNA into the cytoplasm of cells. Efficient gene silencing has been achieved using siRNA immobilized PGNs, suggesting the potential applications of in vitro gene regulation by an external NIR stimulus.
DOI
10.1039/c4cc07155g
Appears in Collections:
약학대학 > 약학과 > Journal papers
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