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Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice

Title
Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice
Authors
Kang J.M.Jung J.-C.Kim H.Lim H.Jang S.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2008
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 31, no. 9, pp. 1098 - 1107
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
In this study, we investigated the neuroprotective effect of a benzylideneacetophenone derivative, JC3, in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD). C57BL/6 mice were treated with MPTP (30 mg/kg, i.p.) for 5 consecutive days. JC3 (10 mg/kg, i.p.) treatment was initiated 2 h after the first administration of MPTP and then at 24-h intervals for 3 consecutive days. The mice were sacrificed for analyses 7 days after the last MPTP injection. Immunohistochemistry and Western blot were used to determine the expression levels of tyrosine hydroxylase (TH), dopamine transporter (DAT), OX-42 (a marker of microglial activation), and glial fibrillary acid protein (GFAP, a marker of astrocyte activation) in the substantia nigra (SN) and striatum (ST). The results of these experiments demonstrated that JC3 restored the decreased TH-immunoreactivity (IR) and DAT and JC3 attenuated the increase in OX-42, GFAP, and COX-2 on the SN and ST on day 7 post-MPTP injection. These results suggest that JC3 can be a neuroprotective agent in an MPTP-induced model of PD. © 2008 The Pharmaceutical Society of Korea.
DOI
10.1007/s12272-001-1275-5
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의학전문대학원 > 의학과 > Journal papers
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