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Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice
- Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice
- Kang J.M.; Jung J.-C.; Kim H.; Lim H.; Jang S.; Oh S.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- Archives of Pharmacal Research
- vol. 31, no. 9, pp. 1098 - 1107
- SCIE; SCOPUS; KCI
- In this study, we investigated the neuroprotective effect of a benzylideneacetophenone derivative, JC3, in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD). C57BL/6 mice were treated with MPTP (30 mg/kg, i.p.) for 5 consecutive days. JC3 (10 mg/kg, i.p.) treatment was initiated 2 h after the first administration of MPTP and then at 24-h intervals for 3 consecutive days. The mice were sacrificed for analyses 7 days after the last MPTP injection. Immunohistochemistry and Western blot were used to determine the expression levels of tyrosine hydroxylase (TH), dopamine transporter (DAT), OX-42 (a marker of microglial activation), and glial fibrillary acid protein (GFAP, a marker of astrocyte activation) in the substantia nigra (SN) and striatum (ST). The results of these experiments demonstrated that JC3 restored the decreased TH-immunoreactivity (IR) and DAT and JC3 attenuated the increase in OX-42, GFAP, and COX-2 on the SN and ST on day 7 post-MPTP injection. These results suggest that JC3 can be a neuroprotective agent in an MPTP-induced model of PD. © 2008 The Pharmaceutical Society of Korea.
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