Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 오세관 | * |
dc.date.accessioned | 2016-12-06T02:12:23Z | - |
dc.date.available | 2016-12-06T02:12:23Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0253-6269 | * |
dc.identifier.other | OAK-5068 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232994 | - |
dc.description.abstract | In this study, we investigated the neuroprotective effect of a benzylideneacetophenone derivative, JC3, in a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD). C57BL/6 mice were treated with MPTP (30 mg/kg, i.p.) for 5 consecutive days. JC3 (10 mg/kg, i.p.) treatment was initiated 2 h after the first administration of MPTP and then at 24-h intervals for 3 consecutive days. The mice were sacrificed for analyses 7 days after the last MPTP injection. Immunohistochemistry and Western blot were used to determine the expression levels of tyrosine hydroxylase (TH), dopamine transporter (DAT), OX-42 (a marker of microglial activation), and glial fibrillary acid protein (GFAP, a marker of astrocyte activation) in the substantia nigra (SN) and striatum (ST). The results of these experiments demonstrated that JC3 restored the decreased TH-immunoreactivity (IR) and DAT and JC3 attenuated the increase in OX-42, GFAP, and COX-2 on the SN and ST on day 7 post-MPTP injection. These results suggest that JC3 can be a neuroprotective agent in an MPTP-induced model of PD. © 2008 The Pharmaceutical Society of Korea. | * |
dc.language | English | * |
dc.title | Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 31 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 1098 | * |
dc.relation.lastpage | 1107 | * |
dc.relation.journaltitle | Archives of Pharmacal Research | * |
dc.identifier.doi | 10.1007/s12272-001-1275-5 | * |
dc.identifier.wosid | WOS:000259364900004 | * |
dc.identifier.scopusid | 2-s2.0-52649158701 | * |
dc.author.google | Kang J.M. | * |
dc.author.google | Jung J.-C. | * |
dc.author.google | Kim H. | * |
dc.author.google | Lim H. | * |
dc.author.google | Jang S. | * |
dc.author.google | Oh S. | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.date.modifydate | 20240118133340 | * |