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The role of Nox4 in oxidative stress-induced MUC5AC overexpression in human airway epithelial cells

Title
The role of Nox4 in oxidative stress-induced MUC5AC overexpression in human airway epithelial cells
Authors
Hyun J.K.Park Y.-D.Uk Y.M.Kim J.-H.Ju H.J.Lee J.-G.Yun S.B.Yoon J.-H.
Ewha Authors
배윤수
SCOPUS Author ID
배윤수scopus
Issue Date
2008
Journal Title
American Journal of Respiratory Cell and Molecular Biology
ISSN
1044-1549JCR Link
Citation
vol. 39, no. 5, pp. 598 - 609
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Mucus hypersecretion is a prominent manifestation in patients with chronic inflammatory airway diseases, and MUC5AC is a major airway mucin. It is well known that reactive oxygen species (ROS) may be involved in the pathogenesis of various inflammatory airway diseases. The purpose of this study was to identify which secreted mucin genes are induced by exogenous hydrogen peroxide and the mechanism by which these genes are up-regulated in normal human nasal epithelial (NHNE) cells. Exogenous H2O2 induced the ligand-independent activation of epidermal growth factor receptors (EGFR) and the subsequent activation of ERK1 mitogen-activated protein kinase, resulting in the induction of intracellular ROS generation. Through this signal pathway, exogenous H2O2 markedly induced overexpression of the MUC5AC gene alone. In addition, Nox4, a subtype of nonphagocytic NADPH oxidase, was found to play a key role in intracellular ROS generation and exogenous H2O2-induced MUC5AC gene expression in NHNE cells.
DOI
10.1165/rcmb.2007-0262OC
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자연과학대학 > 생명과학전공 > Journal papers
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