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Identification of differentially expressed proteins in the heart of translationally controlled tumor protein over-expressing transgenic mice

Title
Identification of differentially expressed proteins in the heart of translationally controlled tumor protein over-expressing transgenic mice
Authors
Cheon M.S.Suh J.-K.Kim M.-J.Kim S.H.Lee K.
Ewha Authors
이경림
SCOPUS Author ID
이경림scopus
Issue Date
2008
Journal Title
Biomedical Chromatography
ISSN
0269-3879JCR Link
Citation
vol. 22, no. 10, pp. 1091 - 1099
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
We previously reported that transgenic (TG) mice over-expressing translationally controlled tumor protein (TCTP) developed systemic arterial hypertension at about 6 weeks after birth. In the present study, we identi?ed, using proteomics technologies, 24 other proteins that were differentially expressed in the heart of TCTP over-expressing TG mice. These 24 proteins are involved in a variety of biological processes such as reactive oxygen species metabolism, cytoskeleton organization, fatty acid metabolism, amino acid metabolism and energy metabolism. We determined protein expression levels of the peroxiredoxin (Prx)2, Prx3, myosin light chain 1, stress protein (heat shock protein) 25K, and T-complex protein 1 alpha subunit by western blot analysis. Over-expression of TCTP probably regulates the expression of other proteins which play a pivotal role in a variety of cellular functions in TCTP over-expressing TG mice. Copyright © 2008 John Wiley & Sons, Ltd.
DOI
10.1002/bmc.1029
Appears in Collections:
약학대학 > 약학과 > Journal papers
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