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New biocompatible polypyrrole-based films with good blood compatibility and high electrical conductivity

Title
New biocompatible polypyrrole-based films with good blood compatibility and high electrical conductivity
Authors
Mao C.Zhu A.Wu Q.Chen X.Kim J.Shen J.
Ewha Authors
김진흥Xiang Bai Chen
SCOPUS Author ID
김진흥scopus
Issue Date
2008
Journal Title
Colloids and Surfaces B: Biointerfaces
ISSN
0927-7765JCR Link
Citation
vol. 67, no. 1, pp. 41 - 45
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A novel O-butyryl chitosan (OBCS)-grafted polypyrrole (PPy) film was described. The immobilization was accomplished by photocrosslinking the OBCS onto PPy films under ultraviolet light irradiation. The surfaces of OBCS-grafted PPy film were characterized by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and electron spectroscopy for chemical analysis (ESCA). The blood compatibility of the OBCS-grafted PPy film was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments in vitro. These results have demonstrated that the surface with immobilized OBCS shows much less platelet adhesive and fibrinogen adsorption compared to the control surface. The bulk conductivity values of PPy films were measured by a modified four-probe method. The composite films have both good blood compatibility and high electrical conductivity that make them suitable for using as potential biomaterials, such as electrically conducting blood vessel and functionally haemocompatible substrate of biosensor used directly in whole blood. © 2008 Elsevier B.V. All rights reserved.
DOI
10.1016/j.colsurfb.2008.07.012
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자연과학대학 > 화학·나노과학전공 > Journal papers
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