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Synthesis, structural characterization and biological evaluation of N-protected cyclopropylethylcarbamates as potential histone deacetylase inhibitor

Title
Synthesis, structural characterization and biological evaluation of N-protected cyclopropylethylcarbamates as potential histone deacetylase inhibitor
Authors
Jung J.-C.Moon H.-I.Oh S.
Ewha Authors
오세관
SCOPUS Author ID
오세관scopus
Issue Date
2008
Journal Title
Chemical Biology and Drug Design
ISSN
1747-0277JCR Link
Citation
vol. 72, no. 6, pp. 592 - 595
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A simple synthesis involving a key coupling reaction and biological activity of N-protected cyclopropylethylcarbamates (18-21) are described. The key fragments are amine·HCl salt (13) and acids (16 and 17) which were smoothly coupled by using 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3- tetramethyluroniumhexafluorophosphate in high yield. We have found that the in vitro growth inhibitory potency of new compound 19 exhibited good histone deacetylase activity. © 2008 The Authors.
DOI
10.1111/j.1747-0285.2008.00743.x
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
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