Synthesis, structural characterization and biological evaluation of N-protected cyclopropylethylcarbamates as potential histone deacetylase inhibitor

Abstract

A simple synthesis involving a key coupling reaction and biological activity of N-protected cyclopropylethylcarbamates (18-21) are described. The key fragments are amine·HCl salt (13) and acids (16 and 17) which were smoothly coupled by using 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3- tetramethyluroniumhexafluorophosphate in high yield. We have found that the in vitro growth inhibitory potency of new compound 19 exhibited good histone deacetylase activity. © 2008 The Authors.