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A micellar prodrug of paclitaxel conjugated to cyclotriphosphazene

Title
A micellar prodrug of paclitaxel conjugated to cyclotriphosphazene
Authors
Jun Y.J.Min J.H.Ji D.E.Yoo J.H.Kim J.H.Lee H.J.Jeong B.Sohn Y.S.
Ewha Authors
손연수이화정정병문
SCOPUS Author ID
손연수scopus; 이화정scopus; 정병문scopus
Issue Date
2008
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
vol. 18, no. 24, pp. 6410 - 6413
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A novel water soluble and biodegradable cyclotriphosphazene-paclitaxel conjugate was prepared by reacting 2′-succinyl paclitaxel with cyclotriphosphazenes bearing equimolar glycyl-l-lysine and methoxy poly(ethylene glycol) as side groups. The macromolecular conjugate was found to self-assemble in aqueous solution to form stable micelles with a mean hydrodynamic diameter of 24.7 nm and a low critical micelle concentration of 10 mg/L. The present conjugate exhibited lower than free paclitaxel but reasonably high in vitro cytotoxicity against selected human tumor cells due to their hydrolytic degradation in PBS solution. © 2008 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2008.10.077
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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