Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이공주 | - |
dc.date.accessioned | 2016-11-30T02:11:29Z | - |
dc.date.available | 2016-11-30T02:11:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1535-9476 | - |
dc.identifier.other | OAK-5238 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232900 | - |
dc.description.abstract | Identification of post-translational modifications (PTMs) is important to understanding the biological functions of proteins. MS/MS is a useful tool to identify PTMs. Most existing search tools are restricted to take only a few types of PTMs as input. Here we describe a new algorithm, called MODi (pronounced "mod eye"), that rapidly searches for all known types of PTMs at once without limiting a multitude of modified sites in a peptide. MODi introduces the notion of a tag chain, a combination structure made from multiple sequence tags, that effectively localizes modified regions within a spectrum and overcomes de novo sequencing errors common in tag-based approaches. MODi showed its performance competence by identifying various types of PTMs in analysis of PTM- rich proteins such as glyceraldehyde-3-phosphate dehydrogenase and lens protein. We demonstrated that MODi innovatively manages the computational complexity of identifying multiple PTMs in a peptide, which may exist in a greater variety than usually expected. In addition, it is suggested tha MODi has great potential to discover novel modifications. © 2008 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.language | English | - |
dc.title | Unrestrictive identification of multiple post-translational modifications from tandem mass spectrometry using an error-tolerant algorithm based on an extended sequence tag approach | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 7 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2452 | - |
dc.relation.lastpage | 2463 | - |
dc.relation.journaltitle | Molecular and Cellular Proteomics | - |
dc.identifier.doi | 10.1074/mcp.M800101-MCP200 | - |
dc.identifier.wosid | WOS:000261328200014 | - |
dc.identifier.scopusid | 2-s2.0-58149307960 | - |
dc.author.google | Na S. | - |
dc.author.google | Jeong J. | - |
dc.author.google | Park H. | - |
dc.author.google | Lee K.-J. | - |
dc.author.google | Paek E. | - |
dc.contributor.scopusid | 이공주(7501497635;57191532162) | - |
dc.date.modifydate | 20230208115507 | - |