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Antihistamine activities of iminodiacetamide derivatives

Title
Antihistamine activities of iminodiacetamide derivatives
Authors
Rhee S.-J.Kam Y.L.Seo Y.H.Park Choo H.-Y.
Ewha Authors
박혜영
SCOPUS Author ID
박혜영scopus
Issue Date
2008
Journal Title
Biomolecules and Therapeutics
ISSN
1976-9148JCR Link
Citation
vol. 16, no. 4, pp. 416 - 424
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A series of N,N′-substituted iminodiacetamide derivatives was synthesized and evaluated their inhibitory effects on the histamine-induced smooth muscle contraction in guinea-pig ileum and on the histamine release from IgE-sensitized RBL-2H3 cells (rat basophilic leukemia cell line). Compounds A3, A4 and A5 which have 1-(4-chlorobenzhydryl) piperazine moiety, showed both moderate antihistamine activity and histamine release inhibitory activity.
DOI
10.4062/biomolther.2008.16.4.416
Appears in Collections:
약학대학 > 약학과 > Journal papers
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