Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서은경 | * |
dc.contributor.author | 한아름 | * |
dc.date.accessioned | 2016-11-26T02:11:32Z | - |
dc.date.available | 2016-11-26T02:11:32Z | - |
dc.date.issued | 2008 | * |
dc.identifier.issn | 0253-3073 | * |
dc.identifier.other | OAK-18081 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232831 | - |
dc.description.abstract | We previously reported that anti-inflammatory properties of poncirin, isolated from fruit of Poncirus trifoliata, might be the result from the inhibition of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-á (TNF-α) and interlukin-6 (IL-6) expression via the down-regulation of NF-κB binding activity. In this study, we investigated whether poncirin has an inhibitory effect on the production of pro-inflammatory mediators ex vivo and whether poncirin could relieve the symptoms of dextran sulfate sodium (DSS)-induced colitis in mice model of inflammatory bowel disease. Poncirin significantly inhibited the productions of NO, IL-6 and TNF-α in lipopolysaccharide (LPS)-induced mouse peritoneal macrophage. In addition, poncirin-treated mice when compared to control mice not receiving treatment recovered better from the weight loss caused by DSS-induced colitis. Changes in disease activity index (DAI) of poncirin-treated mice were also more favorable than for control mice and were comparable with mice treated with a typical anti-inflammatory-drug, 5-aminosalichylic acid (5-ASA). In addition, suppression of plasma NO and IL-6 productions of poncirin-treated mice was also observed in DSS-induced colitis. These results suggest that poncirin has potentially useful anti-inflammatory effects mediated by suppression of inflammatory mediator productions. | * |
dc.language | Korean | * |
dc.title | Poncirin alleviates the symptoms of dextran sulfate sodium - Induced colitic mice | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 39 | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 104 | * |
dc.relation.lastpage | 109 | * |
dc.relation.journaltitle | Korean Journal of Pharmacognosy | * |
dc.identifier.scopusid | 2-s2.0-76749169437 | * |
dc.author.google | Kim J.-B. | * |
dc.author.google | Cho W. | * |
dc.author.google | Han A.-R. | * |
dc.author.google | Seo E.-K. | * |
dc.author.google | Lee K.-T. | * |
dc.contributor.scopusid | 서은경(7005953758) | * |
dc.contributor.scopusid | 한아름(56278315000;34769874800) | * |
dc.date.modifydate | 20240130112016 | * |