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Synthesis and conformational analysis of novel 2',3'-didehydo-2',3'-dideoxy-4'-selenonucleosides.

Title
Synthesis and conformational analysis of novel 2',3'-didehydo-2',3'-dideoxy-4'-selenonucleosides.
Authors
Ko Y.J.Choi W.J.Jun J.H.Zhao L.X.Jeong L.S.
Ewha Authors
정낙신최원준
Issue Date
2008
Journal Title
Nucleic acids symposium series (2004)
ISSN
1746-8272JCR Link
Citation
no. 52, pp. 555 - 556
Indexed
SCOPUS scopus
Abstract
The structure of 2',3'-didehydro-2',3'-dideoxynucleosides (d4Ns) was applied to design the novel bioisosteric 4'-seleno-d4Ns as potential inhibitors of human immunodeficiency virus reverse transcriptase (HIV RT). Conversion of 2',3'-dihydroxyl groups of 4'-selenoribofuranosyl pyrimidines into the olefin was accomplished by treatment of cyclic 2',3'-thiocarbonate with 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine.
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약학대학 > 약학과 > Journal papers
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