Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-11-25T02:11:29Z | - |
dc.date.available | 2016-11-25T02:11:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1746-8272 | - |
dc.identifier.other | OAK-18110 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232818 | - |
dc.description.abstract | We have established structure-activity relationships of novel truncated D-4'-thioadenosine derivatives from D-mannose as potent and selective A(3) adenosine receptor (AR) antagonists. At the human A(3) AR, most of N(6)-substituted analogues showed high potency and selectivity and acted as pure antagonists in a cyclic AMP functional assay. Among compounds tested, 2-chloro-N(6)-3-chlorobenzyl and N(6)-3-chlorobenzyl analogues displayed very high binding affinities (K(i) = 1.66 nM and 1.5 nM, respectively) at the human A(3) AR. Truncated 4'-thioadenosine derivatives studied here are regarded as an excellent template for the design of novel A(3) AR antagonists to act at both human and murine species. | - |
dc.language | English | - |
dc.title | Design and synthesis of truncated 4'-thioadenosine derivatives as potent and selective A3 adenosine receptor antagonists. | - |
dc.type | Article | - |
dc.relation.issue | 52 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 641 | - |
dc.relation.lastpage | 642 | - |
dc.relation.journaltitle | Nucleic acids symposium series (2004) | - |
dc.identifier.scopusid | 2-s2.0-78649409485 | - |
dc.author.google | Hou X. | - |
dc.author.google | Pal S. | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Tipnis A. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |