Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정낙신 | - |
dc.contributor.author | 최원준 | - |
dc.date.accessioned | 2016-11-25T02:11:29Z | - |
dc.date.available | 2016-11-25T02:11:29Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1746-8272 | - |
dc.identifier.other | OAK-18112 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232817 | - |
dc.description.abstract | The highly selective A(3) receptor agonist, 4'-thio-Cl-IB-MECA was successfully converted into selective A(3) receptor antagonists by appending a second N-alkyl group on the 5'-uronamide position. This result indicates that the hydrogen bonding ability of the 5'-uronamide is essential for the conformational change required for the receptor activation. Among compounds tested, a N(6)-(3-bromobenzyl) derivative with 5'-dimethyluronamide exhibited the highest binding affinity (K(i) = 9.32 nM) at the human A(3) AR with very low binding affinities to other AR subtypes. | - |
dc.language | English | - |
dc.title | Synthesis of 2-chloro-N6-substituted-4'-thioadenosine-5'-N, N-dialkyluronamides as potent and selective A3 adenosine receptor antagonists. | - |
dc.type | Article | - |
dc.relation.issue | 52 | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 645 | - |
dc.relation.lastpage | 646 | - |
dc.relation.journaltitle | Nucleic acids symposium series (2004) | - |
dc.identifier.scopusid | 2-s2.0-78649433955 | - |
dc.author.google | Choi W.J. | - |
dc.author.google | Lee H.W. | - |
dc.author.google | Hou X. | - |
dc.author.google | Kim H.O. | - |
dc.author.google | Jacobson K.A. | - |
dc.author.google | Jeong L.S. | - |
dc.contributor.scopusid | 정낙신(16028528200) | - |
dc.contributor.scopusid | 최원준(55732412300;57211762651) | - |
dc.date.modifydate | 20230627112239 | - |