Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김준수 | * |
dc.date.accessioned | 2016-11-18T02:11:50Z | - |
dc.date.available | 2016-11-18T02:11:50Z | - |
dc.date.issued | 2016 | * |
dc.identifier.issn | 0378-5173 | * |
dc.identifier.other | OAK-19457 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/232772 | - |
dc.description.abstract | Here we report that new dual-targeted theranostic anti-cancer agents can be produced by simple conjugation of photosensitizers with tryptophan-containing peptide ligands via cyclic disulfide linkages. In the proof-of-concept study, photosensitizers conjugated with EGFR-targeting peptide GE11 (C-EGFR) were in close proximity with tryptophan residues in the conjugate, resulting in quenching of its fluorescence and singlet oxygen generation. C-EGFR specifically binds to target receptors on the cancer cell surface, after which it is internalized via receptor-mediated endocytosis. Intracellular cleavage of cyclic disulfide bonds allows separation of the photosensitizers from the tryptophan residue, after which they emit near-infrared (NIR) fluorescence and produce a phototoxic effect in the target cells. This strategy enabled us to accomplish simultaneous real-time NIR fluorescence imaging of EGFR-overexpressing cancer cells with high contrast and selective photodynamic therapy © 2016 Elsevier B.V. | * |
dc.language | English | * |
dc.publisher | Elsevier | * |
dc.subject | Activatable | * |
dc.subject | EGFR target | * |
dc.subject | Fluorescence imaging | * |
dc.subject | Photodynamic therapy | * |
dc.subject | Theranostics | * |
dc.title | Photosensitizer-conjugated tryptophan-containing peptide ligands as new dual-targeted theranostics for cancers | * |
dc.type | Article | * |
dc.relation.issue | 42737.0 | * |
dc.relation.volume | 513 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 584 | * |
dc.relation.lastpage | 590 | * |
dc.relation.journaltitle | International Journal of Pharmaceutics | * |
dc.identifier.doi | 10.1016/j.ijpharm.2016.09.071 | * |
dc.identifier.wosid | WOS:000386779700059 | * |
dc.identifier.scopusid | 2-s2.0-84989182839 | * |
dc.author.google | Kim J. | * |
dc.author.google | Chae J. | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Goh S.-H. | * |
dc.author.google | Choi Y. | * |
dc.contributor.scopusid | 김준수(23670121600) | * |
dc.date.modifydate | 20240215165024 | * |