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Population pharmacokinetics and analgesic potency of oxycodone

Title
Population pharmacokinetics and analgesic potency of oxycodone
Authors
Choi, Byung-MoonLee, Yong-HunAn, Sang-MeeLee, Soo-HanLee, Eun-KyungNoh, Gyu-Jeong
Ewha Authors
이은경
SCOPUS Author ID
이은경scopus
Issue Date
2017
Journal Title
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
ISSN
0306-5251JCR Link1365-2125JCR Link
Citation
vol. 83, no. 2, pp. 314 - 325
Keywords
analgesiamodeloxycodonepharmacokineticpotency
Publisher
WILEY-BLACKWELL
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
AIMS This prospective study aimed to characterize the population pharmacokinetics of intravenous oxycodone and to determine the minimum effective concentration (MEC) and minimum effective analgesic concentration (MEAC) of oxycodone for major open intra-abdominal surgery. METHODS In the pharmacokinetic study, patients were administered intravenous oxycodone (0.1 mg kg(-1)), and arterial blood was sampled at pre-set intervals. In the analgesic-potency study, patients were administered intravenous oxycodone (0.1 mg kg(-1)) 30 min before the end of the surgery, were placed in the postoperative anaesthesia care unit (PACU), and were asked to rate their pain every 10 min using a visual analogue scale (0 = no pain, 10 = most severe pain). On the first occasion that wound pain at rest and during compression was rated as >= 3 or >= 5, respectively, the first blood sample was obtained to determine the MEC. A second blood sample was obtained after titration with 2 mg of oxycodone to yield wound pain <3 at rest and <5 during wound compression, and MEAC was determined. MEC and MEAC were determined again in each patient. RESULTS In the population pharmacokinetic study (n = 54), oxycodone plasma concentration over time was well described by a threecompartment mammillary model. Lean body mass and age were significant covariates for the volume of distribution and metabolic clearance of the pharmacokinetic model of oxycodone, respectively. The analgesic-potency study (n = 50) showed that the median (95% CI) MEC and MEAC were 31.5 (19.2-42.8) and 74.1 (29.2-128.3) ng ml(-1) (first measurements) and 63.4 (15.6-120.1) and 76.1 (32.9-132.7) ng ml(-1) (second measurements), respectively. CONCLUSIONS In major intra-abdominal open surgery, the MEAC and analgesic potency of oxycodone were 75 ng ml(-1) and 60 ng ml(-1), respectively.
DOI
10.1111/bcp.13101
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자연과학대학 > 통계학전공 > Journal papers
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