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Theranostic Bioabsorbable Bone Fixation Plate with Drug-Layered Double Hydroxide Nanohybrids

Title
Theranostic Bioabsorbable Bone Fixation Plate with Drug-Layered Double Hydroxide Nanohybrids
Authors
Kim M.H.Hur W.Choi G.Min H.S.Choi T.H.Choy Y.B.Choy J.-H.
Ewha Authors
최진호
SCOPUS Author ID
최진호scopus
Issue Date
2016
Journal Title
Advanced Healthcare Materials
ISSN
2192-2640JCR Link
Citation
vol. 5, no. 21, pp. 2765 - 2775
Keywords
bioabsorbable bone fixation platesbone regenerationlayered double hydroxiderisedronateX-ray visibility
Publisher
Wiley-VCH Verlag
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A bioabsorbable polymeric bone plate enabled with both diagnostic and therapeutic functionalities (radiopacity and sustained drug release, respectively) is proposed. To this end, a drug–inorganic nanohybrid (RS-LDH) is examined as a theranostic agent by intercalating an anti-resorptive bone remodeling drug, risedronate (RS) into a layered double hydroxide (LDH) via an ion-exchange reaction. The RS-LDH is prepared as a sheet with a biodegradable polymer, poly(lactic-co-glycolic acid), and is then attached onto the clinically approved bioabsorbable bone plate to produce the theranostic plate. Because of the presence of the metals in the LDH, the theranostic plate results in discernible in vivo X-ray images for up to four weeks after implantation. Concurrently, bone regeneration is also significantly improved compared with the other control groups, likely because of this material's sustained drug-release property. The theranostic plate is also largely biocompatible, similar to the plate already approved for clinical use. It is concluded that the combination of a biodegradable bone plate with RS-LDH nanohybrids can constitute a promising system with theranostic ability in both X-ray diagnosis and expedited bone repair. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI
10.1002/adhm.201600761
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자연과학대학 > 화학·나노과학전공 > Journal papers
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