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Transcriptional modulation of regulatory T cell development by novel regulators NR4As

Title
Transcriptional modulation of regulatory T cell development by novel regulators NR4As
Authors
Won H.Y.Hwang E.S.
Ewha Authors
황은숙
SCOPUS Author ID
황은숙scopus
Issue Date
2016
Journal Title
Archives of Pharmacal Research
ISSN
0253-6269JCR Link
Citation
vol. 39, no. 11, pp. 1530 - 1536
Keywords
Foxp3Immune homeostasisInflammation and cancerNuclear receptor 4ARegulatory T cells
Publisher
Pharmaceutical Society of Korea
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
Regulatory T (Treg) cells with high expression of both CD25 and Foxp3 are developed in the thymus and also peripheral tissues. Treg cells suppress the activation and functions of effector T cells raised against specific antigens and are crucial for maintaining immune homeostasis. Treg cell development is associated with the induction of and epigenetic alterations of forkhead transcription factor Foxp3. Foxp3 expression is increased by the activation of several transcription factors including nuclear factor-kappa B (NF-κB), nuclear factor of activated T cells (NFAT), and Smad3 in response to various signals such as TGFβ, retinoic acid, and rapamycin. Recently, the orphan nuclear receptor 4A proteins (NR4As) including NR4A1 (Nur77), NR4A2 (Nurr1), and NR4A3 (Nor1) are reported to regulate Treg cell development through activation of Foxp3 and have therapeutic potentials in treating immune disorders. This review summarizes the function and regulatory mechanisms of Treg cells and also implicates current advances in immunomodulatory functions of NR4As and their therapeutic potentials in inflammation and cancer. © 2016, The Pharmaceutical Society of Korea.
DOI
10.1007/s12272-016-0803-z
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약학대학 > 약학과 > Journal papers
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